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  • Volume 1
  •  Issue 3
    • Publication Date: March 2007


Effective Therapy with Thalidomide/Lovastatin in a Patient with Primary Plasma Cell Leukemia


Marek Hus, Marta Szostek, Norbert Grzasko, Dariusz Jawniak, Malgorzata Kowal, Anna Dmoszynska

A 61-year-old man with plasma cell leukemia was treated with thalidomide, lovastatin and dexamethasone. Lovastatin was added to the usual thalidomide/dexamethasone regimen after obtaining the results of short-term culture, which revealed that thalidomide/lovastatin produced a higher rate of apoptosis, compared with apoptosis induced by each drug alone. Thirty-six months after the beginning of the therapy, the patient is still in complete hematologic remission.

Key words: Apoptosis, Dexamethasone, Myeloma


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